Programming Cell Therapies. At Scale.

OverT is redefining what's possible for treating solid tumors with programmed, off-the-shelf cell therapies.

Our science

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OverT Bio is pioneering next-generation cell therapies to overcome the toughest challenges in solid tumors.

We combine massively-parallel, AI-powered discovery of new genetic programs with scalable manufacturing to deliver safe, effective, and accessible treatments.

What sets us apart

Genome-Scale Discovery

We test every gene in the human genome using advanced, AI-powered models of protein function to uncover new genetic programs that boost T cell persistence and resistance to immunosuppression.

Smarter Receptor Design

By analyzing data from thousands of patient tumors, we engineer diverse receptors and deeply profile them with multimodal single-cell tools to measure both expression and tumor-killing function.

Harnessing Gamma Delta T Cells

Our therapies leverage gamma delta T cells, which naturally target tumors through both innate and adaptive mechanisms and are inherently better suited for tissue infiltration.

Scalable, Off-the-Shelf Therapy

We’re building a naturally allogeneic cell therapy that reduces time to treatment and cost—offering the scalability of a biologic with the curative potential of cell therapy.

Advancing scalable, off-the-shelf cell therapies to help patients

Ovarian Cancer

OVT–101

Modality CLDN6 — CAR–T

First–in–human anticipated H1 '27

Solid Tumors

OVT–201

Modality Non–MHC TCR–T

Candidate nomination anticipated H1 '27

Discovery
Candidate nomination
IND–enabling
Early clinical

Our team includes pioneers in T cell engineering and cell therapy development

meet the team
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